Endothelial Cells in Health and Disease

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J Am Coll Cardiol. Function of the Endothelial Layer.

Endothelial Dysfunction

Causes of Dysfunction. Associated Disorders and Habits. View All.

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Thanks for your feedback! Sign Up. What are your concerns? Article Sources. Coronary Microvascular Dysfunction: an Update. Eur Heart J ; J Am Coll Cardiol ; e Continue Reading. All About Prinzmetal or Vasospastic Angina. Myocardial ischemia and vessel degeneration are major challenges in aging populations. We are focussing on new approaches to prevent heart and vessel degeneration and to protect vascular function, particularly endothelial cell function.

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An early pathophysiological event in the development of atherosclerosis is endothelial dysfunction and vessel wall inflammation. A key compound modulating the underlying interaction of leukocytes and the endothelium is the nucleoside adenosine. Our goal is to clarify how various pharmacological, endogenous and dietary compounds may protect the endothelium via modulation of adenosine metabolism or membrane transport.

Another major issue in the context of vessel transplantation is the impact of cold storage on endothelial structure and function. We are testing newly designed solutions which better protect the endothelial cells during extended periods of cold storage. Recent progress of our lab documents the feasibility to maintain endothelial function of human vessel segments for more than 1 week, potentially benefitting vessel recipients with proper vessel grafts in the future.

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This team consists of staff with mainly technical background. We are a scientific-technical research department in immediate cooperation with medical research.

Our specialty is the development of optical imaging modalities and sensors and their integration into apparatuses for living cells, isolated organs, in-vivo experiments and non-invasive human measurements. In addition to established applications in ophthalmology and dermatology, new Optical Coherence Tomography OCT developments in the domain of atherosclerosis diagnostics, endoscopy, intensive care medicine and oncology are in development.

Our main fields of research are:. Endothelial cells play a major role in the development and differentiation of the vascular system. Divya Divya. Show More.

New Concepts of the Endothelium in Health and Disease (John F. Keaney, MD) March 23, 2017)

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Endothelial cell in health & disease seminar

No notes for slide. Endothelium in health and diseases 1. P PG in Pathology 2. Central cells - hematogoniae or hemoblasts 2.

Endothelial fluid shear stress sensing in vascular health and disease

Peripheral cells - angioblasts Endothelial dysfunction 2. Vascular inflammation 3. Hemangiomas -sub cutaneous, capillary, cavernous, arteriovenous, venous, intramuscular, synovial 2. Epitheloid Hemangiomas 3. Angiomatosis 4. Lymphangioma